Hypercalcemia and 13-cis-retinoic acid in post-consolidation therapy of neuroblastoma.
Pediatr Blood Cancer. 2008 Oct 6;
Authors: Marabelle A, Sapin V, Rousseau R, Periquet B, Demeocq F, Kanold J
We report 19 episodes of hypercalcemia in three children treated with 13-cis-retinoic acid (13-cis-RA) as a post-consolidation therapy for high-risk neuroblastoma. There was no concomitant overload in 13-cis-RA blood levels. Blood calcium fell after arrest of 13-cis-RA intake. Half dosage retinoid treatment resumption did not prevent the recurrence of hypercalcemia. Concomitant biological values showed massive bone resorption. Hence, hypercalcemia seemed not secondary to 13-cis-RA overload but rather to inter-individual variability in its interaction with bone metabolism. Current guidelines in case of hypercalcemia are to reduce 13-cis-RA dosage. Instead we propose to maintain the therapeutic dosage, but to shorten the duration of courses. Pediatr Blood Cancer. (c) 2008 Wiley-Liss, Inc.
PMID: 18839433 [PubMed - as supplied by publisher]