Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma.
 

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10-23-08 08:41 AM
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Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma.
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Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma.

Rhinology. 2008 Jun;46(2):153-5

Authors: Sharma S, Lasheen W, Walsh D

Esthesioneuroblastoma (ENB) is a rare malignant neoplasm arising from the olfactory neuroepithelium. ENB has no distinctive clinical picture, but often presents as chronic unilateral nasal obstruction or epistaxis. It has a long natural history; the 5-year survival rates have been estimated at 82%. A number of paraneoplastic syndromes have been described in the setting of ENB. Humoral hypercalcemia of malignancy (HHM) has never been described with ENB before. We describe a case of Kadish Stage C ENB with recurrent Hypercalcemia. The hypercalcemia became refractory to therapy and was the cause of death.

PMID: 18575019 [PubMed - indexed for MEDLINE]