My son just completed his first two weeks of retinoic acid and WOW! it was a rough two weeks. The most common side effects I hear about are the peeling skin and lips, but we didn't have any of that. What we did have was a very very moody and lethargic three year old who had absolutely no desire to even leave his bed accompanied by severe diarrhea and diaper rash unlike any other I have seen. I am convinced that my little man was actually depressed. He was not interested in doing anything other than watching TV in his bed. Today is one day off the meds and what a difference! He's in such a better mood and wanted to be out of his room and interacting with the rest of us for the first time in two weeks. I am so shocked at the difference in just one day. Needless to say, I am not looking forward to the next six months with two weeks of lovely boy alternating with two weeks of scary depressed three year old! I am curious if anyone else has experienced any similar side effects.