Paraneoplastic gastro-intestinal anti-Hu syndrome in neuroblastoma.
Pediatr Blood Cancer. 2008 Nov 6;
Authors: Drukker CA, Heij HA, Wijnaendts LC, Verbeke JI, Kaspers GJ
The anti-Hu syndrome is a well-known paraneoplastic syndrome and may be rarely seen in patients with neuroblastoma. However, it is relatively unknown that anti-Hu antibodies can cause gastro-intestinal signs and symptoms. We report on a child with neuroblastoma who presented with gastro-intestinal disturbances as a result of the anti-Hu syndrome and summaries two similar case reports reported in literature. Neuroblastoma patients with gastro-intestinal disturbances, ranging from constipation to a paralytic ileus, might suffer from the gastro-intestinal anti-Hu syndrome. The causative antibodies can be determined to diagnose or exclude this syndrome, and successful treatment is possible. Pediatr Blood Cancer (c) 2008 Wiley-Liss, Inc.
PMID: 18989884 [PubMed - as supplied by publisher]