Low-dose protracted irinotecan as a palliative chemotherapy for advanced neuroblastoma.
 

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11-08-08 08:56 AM
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Low-dose protracted irinotecan as a palliative chemotherapy for advanced neuroblastoma.
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Low-dose protracted irinotecan as a palliative chemotherapy for advanced neuroblastoma.

J Pediatr Hematol Oncol. 2008 Nov;30(11):853-6

Authors: Osone S, Hosoi H, Tsuchiya K, Misawa A, Iehara T, Sugimoto T

Management of cases of refractory neuroblastoma remains a challenge. As intensive chemotherapy sometimes results in severe regimen-related toxicity and poor quality of life, palliative chemotherapy with modest toxicity may be considered for these cases. We report 2 cases of stage 4 neuroblastoma with poor performance status that received low-dose protracted schedules of irinotecan. This regimen achieved not only disease stabilization but also dramatic improvements of quality of life for significant periods. A low-dose protracted schedule of irinotecan was tolerable even if the patient's performance status was poor, and thus might be useful as a palliative chemotherapy for advanced neuroblastoma.

PMID: 18989163 [PubMed - in process]