Unholy Matrimony: Aurora A and N-Myc as Malignant Partners in Neuroblastoma.
 

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12-30-08 08:44 AM
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Unholy Matrimony: Aurora A and N-Myc as Malignant Partners in Neuroblastoma.
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Unholy Matrimony: Aurora A and N-Myc as Malignant Partners in Neuroblastoma.

Cancer Cell. 2009 Jan 6;15(1):5-6

Authors: Maris JM

Aurora A is a mitotic kinase that is essential for regulation of the G2/M checkpoint. In this issue of Cancer Cell, Otto et al. report that Aurora A interacts with MYCN, a potent oncogene in human neuroblastoma, and sequesters it from proteolytic degradation. This surprising finding further enhances Aurora A's potential as a therapeutic target.

PMID: 19111875 [PubMed - as supplied by publisher]