Unholy Matrimony: Aurora A and N-Myc as Malignant Partners in Neuroblastoma.
Cancer Cell. 2009 Jan 6;15(1):5-6
Authors: Maris JM
Aurora A is a mitotic kinase that is essential for regulation of the G2/M checkpoint. In this issue of Cancer Cell, Otto et al. report that Aurora A interacts with MYCN, a potent oncogene in human neuroblastoma, and sequesters it from proteolytic degradation. This surprising finding further enhances Aurora A's potential as a therapeutic target.
PMID: 19111875 [PubMed - as supplied by publisher]