Ganglioneuroblastoma in a cat: a rare neoplasm treated with electrochemotherapy.
 

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02-04-09 08:59 AM
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Ganglioneuroblastoma in a cat: a rare neoplasm treated with electrochemotherapy.
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Ganglioneuroblastoma in a cat: a rare neoplasm treated with electrochemotherapy.

Vet J. 2008 Nov;178(2):291-3

Authors: Spugnini EP, Citro G, Dotsinsky I, Mudrov N, Mellone P, Baldi A

An 8-year-old male castrated cat was referred for sudden onset of lameness. Physical examination revealed a 1x2x1cm mass originating from a footpad of the right hind leg. A diagnosis of ganglioneuroblastoma was suggested by the tumour appearance following histopathological staining with haematoxylin and eosin and haematoxylin/van Gieson. Immunohistochemical staining for glial fibrillary acidic protein (GFAP), vimentin, neuron-specific enolase (NSE), neurofilament and S100 further confirmed the diagnosis. The staging process did not indicate metastatic spread. The cat was treated with three sessions of electrochemotherapy (ECT) 1 week apart, following local injection of bleomycin. The tumour had completely regressed within 1 week of the third ECT application and remained in remission for 402 days at which time a small recurrence was noted. The animal was given a further session of ECT using intra-lesional cisplatin and again went into remission. It remained tumour free at 450 days. Electrochemotherapy is considered a safe and effective treatment for localised neoplasms of cats and dogs and warrants further investigation.

PMID: 17910926 [PubMed - indexed for MEDLINE]