Apoptosis pathways and neuroblastoma therapy.
 

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02-10-09 08:06 AM
Anonymous
Apoptosis pathways and neuroblastoma therapy.
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Apoptosis pathways and neuroblastoma therapy.

Curr Pharm Des. 2009;15(4):430-5

Authors: Fulda S

Evasion of apoptosis, the cell's intrinsic death program, is a hallmark of human cancers including neuroblastoma. Also, failure to undergo apoptosis may cause treatment resistance, since the cytotoxic activity of anticancer therapies commonly used in the clinic, e.g. chemotherapy, gamma-irradiation or immunotherapy, is predominantly mediated by triggering apoptosis in tumor cells. Therefore, a better understanding of the signaling pathways and molecules that govern apoptosis in neuroblastoma cells is expected to open new avenues for the design of molecular targeted therapies for neuroblastoma.

PMID: 19199970 [PubMed - in process]