Occipital ganglio-neuroblastoma in an adult.
 

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03-06-09 08:24 AM
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Occipital ganglio-neuroblastoma in an adult.
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Occipital ganglio-neuroblastoma in an adult.

Acta Neurochir (Wien). 2009 Mar 5;

Authors: Sabatino G, Lauriola L, Sioletic S, Puca A

INTRODUCTION: Ganglioneuroblastomas (GNBs) are embryonic neoplasms, whose behaviour are not well established; 80% of cases occur in the first decade, while only two cases in the adulthood had been reported. CLINICAL REPORT: This 60-year-old female presented with a 2-month history of headache, vertigo, amnesia. A right brachio-crural hemiparesis, right homonymous hemianopsia and sensorial dysphasia was evident. A CT scan revealed a left occipital lesion. MRI scan was not performed because the patient had an anal sphincter stimulator. Three years before thyroidectomy for a follicular carcinoma was performed. A total body CT scan was negative. A left occipital craniotomy was carried out and a solid mass was totally excised. A diagnosis of GNB was made from histopathological examination and immunohistochemistry. Post-operatively the patient recovered from the hemiparesis while the visual disturbances persisted. She underwent fractioned radiotherapy (60 Gy) and chemotherapy with Temozolomide. She remained disease free 18 months after diagnosis. A CT scan showed no evidence of recurrence. DISCUSSION: Recent observations suggest that in spite of an embryonal appearance, these tumours are circumscribed and have a better prognosis than malignant gliomas.

PMID: 19262982 [PubMed - as supplied by publisher]