Differential Expression of Dicer and Argonaute Genes During the Differentiation of Human Neuroblastoma Cells.
Cell Biol Int. 2009 Apr 22;
Authors: Potenza N, Papa U, Russo A
Dicer and Argonaute 1-4 proteins are key components of the cytoplasmic enzyme machinery responsible for biogenesis and performance of microRNAs. To gain insight into the roles of these proteins in cell differentiation, we investigated possible changes in the expression levels of Dicer and Argonaute genes during the differentiation of cultured neural and glial cells. The results show that the 2 genes are differentially expressed along the 2 differentiation pathways and suggest a prevalent role in neural cell differentiation.
PMID: 19393748 [PubMed - as supplied by publisher]