Bioassay-Guided Isolation and Identification of Desacetylmicrocolin B from Lyngbya cf. polychroa.
Planta Med. 2009 May 8;
Authors: Meickle T, Matthew S, Ross C, Luesch H, Paul V
Bioassay-guided fractionation of a non-polar extract of LYNGBYA cf. POLYCHROA resulted in the isolation of the cytotoxic desacetylmicrocolin B ( 1) as well as the known compounds microcolins A ( 2) and B ( 3). Compound 1 was found to inhibit the growth of HT-29 colorectal adenocarcinoma and IMR-32 neuroblastoma cells with half maximal inhibitory concentration (IC (50)) values of 14 nM for both cancer cell types. Microcolins A and B were found to have little activity against two strains of the marine fungus DENDRYPHIELLA SALINA with LD (50) values above 200 microg/mL. Compounds 1, 2, and 3 were obtained by reverse-phase chromatography and their structures were determined by NMR and MS. In this paper we report the isolation, identification, and biological activity of 1.
PMID: 19431099 [PubMed - as supplied by publisher]