ATG5 expression induced by MDMA (ecstasy), interferes with neuronal differentiation of neuroblastoma cells.
Mol Cells. 2009 May;27(5):571-575
Authors: Chae M, Rhee GS, Jang IS, Kim K, Lee JH, Lee SY, Kim M, Yang J, Park J, Lee SH
The amphetamine derivative 3, 4-methylenedioxymethamphetamine (MDMA) has become a popular recreational drug, and has also been shown to cause serotonergic neurotoxicity. This report shows that MDMA impairs brain development in a whole mouse embryo culture. The results of quantitative real-time PCR analysis showed that autophagy-related protein 5 (Atg5) expression is elevated in mouse embryo and neuroblastoma cells after MDMA treatment. This elevated Atg5 expression interferes with the neuronal differentiation of neuroblastoma cells such as SH-SY5Y and PC12 cells. Thus, our results suggest that the use of MDMA during pregnancy may impair neuronal development via an induction of Atg5 expression.
PMID: 19466606 [PubMed - as supplied by publisher]